Srihari, RMathangi, KSriteja, YRemya, K JMathangi, D CShyamala, R2014-07-172014-07-172014-07Srihari R, Mathangi K, Sriteja Y, Remya K J, Mathangi D C, Shyamala R. Second digit and fourth digit ratio – an adjunct tool to predict obstructive sleep apnea. Indian Journal of Physiology and Pharmacology. 2014 Jul-Sept; 58(3): 292-295.http://imsear.searo.who.int/handle/123456789/152757Obstructive sleep apnea (OSA) is a sleep related breathing disorder associated with high morbidity and mortality. Digit ratio (2D:4D) a sexually dimorphic trait is a putative indicator of prenatal testosterone exposure and adult testosterone level. Present study aimed at investigating the correlation between 2D:4D ratio and OSA based on the study conducted on 290 volunteered participants of both the sexes in the age range of 20-45 years. A significant negative correlation was observed for 2D:4D with OSA related parameters specifically Berlin score, Epworth score and certain key anthropometric measurements, neck circumference (NC) and waist-hip ratio (WHR). The study thus showed that lower 2D:4D ratio, increases risk of developing OSA and hence it can be used as an adjunct tool in the prediction of OSA.enArticle