Padmavathy, BDevraj, N SDevraj, H1992-10-012009-06-011992-10-012009-06-011992-10-01Padmavathy B, Devraj NS, Devraj H. Haematological and erythrocyte membrane changes induced by amiodarone, in rats. Indian Journal of Physiology and Pharmacology. 1992 Oct; 36(4): 276-8http://imsear.searo.who.int/handle/123456789/106641The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.engAmiodarone --pharmacologyAnimalsCholesterol --metabolismErythrocyte Count --drug effectsErythrocyte Membrane --drug effectsHemoglobins --metabolismLeukocyte Count --drug effectsMaleMembrane Fluidity --drug effectsPhospholipids --metabolismRatsRats, WistarSodium-Potassium-Exchanging ATPase --bloodComparative Study