Mathur, VijayGodara, AnkitJethawa, DurgaSharma, S.PVerma, Kalpana2020-09-242020-09-242019-03Mathur Vijay, Godara Ankit, Jethawa Durga, Sharma S.P, Verma Kalpana. Comparison of Oral Ivabradine, Oral Metoprolol and Placebo to Attenuate the Stress Response in Nasal and Laryngeal Surgeries: A Prospective, Randomized, Double Blind Study. International Journal of Medical Research Professionals. 2019 Mar; 5(2): 115-1232454-63642454-6356http://imsear.searo.who.int/handle/123456789/203128Introduction: Nasal surgeries like septoplasty, polypectomyand laryngeal surgeries for removal of vocal nodule, cysts etcare commonly performed. Changes in haemodynamics due tolaryngoscopy and endotracheal intubation are likely to persistduring these procedures. These surgeries also require bloodless field. The present study was conducted to evaluate andcompare the efficacy of oral metoprolol tartrate versus oralivabradine versus placebo in attenuation of haemodynamicresponses during laryngoscopy, tracheal intubation andthroughout nasal and laryngeal surgeries.Methods: This was a prospective, randomized, comparative,double blind study. . Patients were randomly allocated bysimple randomization into 3 groups having 30 patients in each.Neither the patient nor the investigator was aware, whichpatient is allocated into which group and were unaware of thedrug being administered as it was given to the patient by aperson not involved in the study. Data collections were carriedout by investigator in a double blind manner. All the patientswere explained about the anesthesia technique and writteninformed consent was taken. Group 1: Oral Ivabradine 5mgtablet was given orally 2 hours before induction of anaesthesia.Group 2: Oral Metoprolol tartrate 50mg tablet was given orally2 hours before induction of anaesthesia. Group 3: Oral placebowas given 2 hours before induction of anaesthesia.Results and Conclusion: We concluded that both the drugscan be used as an effective premedication, to attenuate thesympathetic response to laryngoscopy, endotrachealintubation, extubation and throughout nasal and laryngealsurgeries. However Metopolol was found to have better controlthan Ivabradine in maintaining the vitals at all points andproviding a good hypotensive effect than ivabradine.IvabradineMetoprololStress ResponseNasal and Laryngeal Surgeries.Journal ArticleIndiaProfessor, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, IndiaJunior Resident, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, IndiaProfessor and HOD, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, IndiaAssistant Professor, Department of Anaesthesiology, Critical Care and Pain Management, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India