James, T JSharma, S PGupta, S KPatro, I K2009-05-282009-05-281992-06-01James TJ, Sharma SP, Gupta SK, Patro IK. 'Dark' cell formation under protein malnutrition: process of conversion and concept of 'semi-dark' type Purkinje cells. Indian Journal of Experimental Biology. 1992 Jun; 30(6): 470-3http://imsear.searo.who.int/handle/123456789/60781This paper deals with some deleterious effects of protein malnourishment in rat cerebellum. Severe protein deprivation enhanced the formation of 'dark' cells in white rats. It is postulated that abnormal changes in the neuronal contents induced by nutritional stress play a vital role in the formation of the 'dark' cells through an intermediary stage, 'semi-dark' cells. Centrophenoxine a lipofuscinolytic agent, however, seems to interfere with the process of formation of 'dark' cells and/or helps reconversion of the 'dark' cells into the normal or 'light' type Purkinje cells.engAnimalsLipofuscin --metabolismMeclofenoxate --pharmacologyProtein Deficiency --metabolismPurkinje Cells --metabolismRatsRats, Inbred StrainsJournal Article