Mansuri, S MRaval, J DGirdhar, A OGandhi, T P1984-10-012009-06-011984-10-012009-06-011984-10-01Mansuri SM, Raval JD, Girdhar AO, Gandhi TP. A study of some pharmacological actions of carbamazepine and sodium valproate. Indian Journal of Physiology and Pharmacology. 1984 Oct-Dec; 28(4): 315-8http://imsear.searo.who.int/handle/123456789/106969Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.engAnimalsAnuraBody Temperature --drug effectsCarbamazepine --pharmacologyCatsCentral Nervous System --drug effectsEvoked Potentials --drug effectsMiceMuscle Contraction --drug effectsNeuromuscular Junction --drug effectsRabbitsRatsSleep --drug effectsTime FactorsValproic Acid --pharmacologyComparative Study