J., SSampson, UJ., K.2020-09-242020-09-242020-02J. S, Sampson U, J. K.. Assessment of levels of Vitamin D and Leptin in comparison of BMI among medical students. International Journal of Medical Research & Review. 2020 Feb; 8(1): 51-562320-86862321-127Xhttp://imsear.searo.who.int/handle/123456789/205373Introduction: Vitamin D is one of fat-soluble vitamin that plays an important role in the absorption of calcium and phosphate. Deficiency of Vitamin D is unrecognized in many parts of the world. Leptin is a hormone which is derived from adipose tissue. Studies have shown that vitamin D has a negative and powerful control on leptin secretion by vitamin D by acting on the adipose tissue. Aim and Objectives: The study was done to study the relationship between Vitamin D and Leptin based on Body mass index among the medical students. Materials and methods: Vitamin D Leptin and Body mass index were the parameters measured in the study group. Individuals with an age group of 19-23 years of both sexes were included in the study. Individuals above the age of 23 years, those with renal and liver disorders, individuals with hormonal disorders, individuals on vitamin D supplementation were excluded in the study. Vitamin D was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Leptin was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. BMI is calculated by the formula weight in kilograms divided by height in metre square. Results: The results have shown that there is a decrease in vitamin D levels with increasing BMI. (pvalue≤0.001). furthermore, there is an increase in leptin levels with an increase in BMI. (pvalue≤0.001). Conclusion: The study has put forth a suggestion that leptin and vitamin D has a causal relationship between them based on Body Mass index. Adequate vitamin D levels will maximize the effect of maintaining normal leptin levels as high levels of leptin could contribute to obesity-related disorders.Vitamin DObesityLeptinJournal ArticleIndiaDr. J. Sivakumar Assistant Professor, Department of Biochemistry, Meenakshi Medical College, Kancheepuram, Tamil Nadu, IndiaDr. Ursula Sampson Professor and Head, Department of Biochemistry, Meenakshi Medical College, Kancheepuram, Tamil Nadu, IndiaMr. J. Kumar Tutor, Department of Biochemistry, Meenakshi Medical College, Kancheepuram, Tamil Nadu, India