Mohapatra, M KSamal, M MPadhiary, K NDash, P CSahoo, G NPatnaik, B C1996-06-012009-05-311996-06-012009-05-311996-06-01Mohapatra MK, Samal MM, Padhiary KN, Dash PC, Sahoo GN, Patnaik BC. Clinicopathological profile of subacute hepatic failure. Journal of the Association of Physicians of India. 1996 Jun; 44(6): 375-7http://imsear.searo.who.int/handle/123456789/91280Twenty two patients of subacute hepatic failure (SAHF), diagnosed when jaundice progressed for more than 8 weeks with appearance of ascites, with or without encephalopathy, along with biochemical evidence of hepatocellular damage, were studied. The male and female ratio was 4.5:1 and majority (45.4%) of cases were between the age group of 41-50. The mean biochemical values were: S.bilirubin; 9.2 +/- 3.8 mg/dl SGOT; 94.4 +/- 25.0 I.U./lit., SGPT; 107.8 +/- 32.7 I.U./lit., S.Protein; 5.2 +/- 3.5 secs. Ascitic fluid analysis showed transudate in 16 (72.7%) and exudate in 6 (27.2%) patients. Bacterial peritonitis was found in 5 (22.7%) patients. Liver biopsy showed bridging and submassive necrosis. The complications developed in the hospital were: renal failure (36.3%), infection (27.2%), G.I. bleeding (18.1%) and encephalopathy (13.6%). The mortality was (86.3%). Out of 3 (13.6%) patients who survived, only two recovered completely and one had biochemical evidence of hepatocellular necrosis after 6 months of follow up.engAcute DiseaseAdultAscites --etiologyBiopsyDiagnosis, DifferentialDisease ProgressionFemaleFollow-Up StudiesHepatic Encephalopathy --etiologyHumansJaundice --etiologyLiver --pathologyLiver Failure --complicationsMaleMiddle AgedProspective StudiesSurvival RateJournal Article