Parasnis, HRaje, BHinduja, I N1992-10-012009-06-021992-10-012009-06-021992-10-01Parasnis H, Raje B, Hinduja IN. Relevance of plasma fibrinogen estimation in obstetric complications. Journal of Postgraduate Medicine. 1992 Oct-Dec; 38(4): 183-5http://imsear.searo.who.int/handle/123456789/115238We present a study of fibrinogen levels in 133 patients who were prone to develop disseminated intravascular coagulation as a result of an underlying complication of pregnancy such as abruptio placentae, pregnancy-induced hypertension, missed abortion, septic abortion, intrauterine fetal death, vesicular mole and amniotic fluid embolism. A high incidence of hypofibrinogenemia was found in cases of abruptio placentae (43.9%) and pregnancy-induced hypertension (25%). Hypofibrinogenemia occurred in 10% cases of intrauterine fetal death within 4 weeks of fetal demise. The use of this simple investigation makes possible the diagnosis of hemostatic failure and also helps to guide replacement therapy during the fibrinopenic state. There were 4 maternal deaths and 12 perinatal losses in this study.engAbruptio Placentae --complicationsDisseminated Intravascular Coagulation --bloodFemaleFetal Death --epidemiologyFibrinogen --analysisHumansHypertension --complicationsIncidencePregnancyPregnancy Complications, Cardiovascular --epidemiologyPregnancy Complications, Hematologic --bloodPregnancy OutcomeProspective StudiesRisk FactorsJournal Article