Patro, NishaSingh, KavitaPatro, Ishan2013-11-182013-11-182013-08Patro Nisha, Singh Kavita, Patro Ishan. Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats. Indian Journal of Experimental Biology. 2013 Aug; 51(8): 606-614.http://imsear.searo.who.int/handle/123456789/149363Polyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.enAstrocytesInfectionsLipopolysaccharideMicrogliaPoly I:CAcute DiseaseAnimalsAnimals, NewbornAntiviral Agents --pharmacologyAstrocytes --drug effectsAstrocytes --immunologyAstrocytes --metabolismChronic DiseaseFemaleGlial Fibrillary Acidic Protein --metabolismHippocampus --drug effectsHippocampus --immunologyHippocampus --metabolismImmunoenzyme TechniquesInflammation --chemically inducedInflammation --immunologyInflammation --pathologyLipopolysaccharides --pharmacologyMicroglia --drug effectsMicroglia --immunologyMicroglia --metabolismPoly I-C --pharmacologyRatsRats, Sprague-DawleyArticle