kidambi, Bharath rajpurohit, VikasBajpai, SwatiNehra, AshimaKarthikeyan, Ganesan2023-07-212023-07-212022-02kidambi Bharath raj, purohit Vikas, Bajpai Swati, Nehra Ashima, Karthikeyan Ganesan. Is the use of high-intensity atorvastatin associated with memory impairment?. Indian Heart Journal. 2022 Feb; 74(1): 66-680019-48322213-3763http://imsear.searo.who.int/handle/123456789/220869High-intensity statins are the cornerstone of medical management in Acute Coronary Syndromes (ACS). However, their effect on neurocognition are less clear. In this prospective observational study, we gave guideline-directed high-intensity atorvastatin 40 mg to middle-aged statin-naïve ACS patients. Memory assessments were performed before and 6 months after statin therapy using 2 validated scales-the PostGraduate Institute Memory Scale (PGI-MS), and the Logical Memory Passage Test (LMPT). There was no significant difference in the mean PGI-MS test scores (baseline 75.4 ± 7.9, 6months 76.5 ± 8.2;p ¼ 0.26) or the overall composite scores (baseline 32.02 ± 3.2, 6months 32.8 ± 3.1; p ¼ 0.20), after 6 months of statin use. There was a small improvement in immediate recall (baseline score 8.5 ± 2.5, 6 months 9.04 ± 1.8; p ¼ 0.05), and delayed recall (baseline 6.1 ± 2.6, 6 months 6.9 ± 1.9, p ¼ 0.002). High-intensity atorvastatin use did not affect memory at 6 months among statin-naïve middle-aged patients with ACS.High-intensity statinsMemory impairmentAtorvastatinMemory lossStatin-induced memory impairmentJournal ArticleIndiaDepartment of Cardiology, SRM Medical College Hospital and Research Centre, Chennai, IndiaDepartment of Cardiology, NIMS Medical College, Jaipur, IndiaGeriatric Medicine, All India Institute of Medical Sciences, New Delhi, IndiaClinical Neuropsychology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, India