Devi, Akoijam TamphasanaYadav, ReenaYadav, AmitaSingh, Yanglem Ajitkumar2020-10-162020-10-162020-01Devi Akoijam Tamphasana, Yadav Reena, Yadav Amita, Singh Yanglem Ajitkumar. Study of maternal serum lipid profile and apolipoprotein a levels and its correlation with fetal growth restriction. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Jan; 9(1): 270-2732320-17702320-1789http://imsear.searo.who.int/handle/123456789/207346Background: This study was aimed to estimate maternal serum lipid profile and apolipoprotein A levels in pregnancies complicated with FGR and to compare the levels with the levels in normal pregnancies.Methods: A prospective observational study was conducted in Lady Hardinge Medical College, New Delhi, in a study group consisting of 30 pregnant women at gestation 32-34 weeks with ultrasound diagnosed FGR and control group consisting of 30 age and gestation matched uncomplicated pregnant women. Maternal serum lipid profile and apolipoprotein A levels were measured and compared between the two groups.Results: Total serum cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and Apolipoprotein A were significantly lower in FGR group compared to normal controls. Mean±SD of total cholesterol was found to be 199.17±49.06 mg/dl in cases and 244.10±53.17 mg/dl in controls. Mean±SD of triglyceride was 200.53±60.25 mg/dl in cases compared to 304.13±69.12 mg/dl in controls. Mean±SD of LDL-Cholesterol was 98.19±37.91 mg/dl in cases and 127.07±47.84 mg/dl in controls. Mean±SD of VLDL-cholesterol was 40.11±12.05 mg/dl in cases and 60.83±13.82 mg/dl in controls. Mean±SD of Apolipoprotein A was 147.71±16.40 mg/dl in cases compared to 163.30±16.07 mg/dl in controls. HDL-cholesterol did not change significantly as its mean±SD was 60.87±15.18 mg/dl in FGR group and 56.20±16.07 mg/dl in control group.Conclusions: The decreased levels of total cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and apolipoprotein A levels may be used as biochemical marker for detection of FGR.Apolipoprotein ACholesterolFetal growth restrictionTriglycerideJournal ArticleIndiaDepartment of Obstetrics and Gynecology, Regional Institute of Medical Sciences, Imphal, Manipur, IndiaDepartment of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, IndiaDepartment of Biochemistry, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India