Lath, RChacko, GChandy, M J2001-06-122009-06-032001-06-122009-06-032001-06-12Lath R, Chacko G, Chandy MJ. Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody. Neurology India. 2001 Jun; 49(2): 144-7http://imsear.searo.who.int/handle/123456789/121610Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.engAdenoma --diagnosisAdolescentAdultAgedAntibodies, MonoclonalChildFemaleHumansKi-67 Antigen --metabolismMagnetic Resonance ImagingMaleMiddle AgedPituitary Neoplasms --diagnosisJournal Article