Thamprajamchit, SChetchotisakd, PThinkhamrop, B2009-05-272009-05-271998-04-12Thamprajamchit S, Chetchotisakd P, Thinkhamrop B. Cefoperazone/sulbactam + co-trimoxazole vs ceftazidime + co-trimoxazole in the treatment of severe melioidosis: a randomized, double-blind, controlled study. Journal of the Medical Association of Thailand. 1998 Apr; 81(4): 265-71http://imsear.searo.who.int/handle/123456789/44434Chotmaihet Thangphaet.A prospective randomized, double-blind, controlled study of cefoperazone/sulbactam (cefoperazone 25 mg/kg/day) + co-trimoxazole (trimethoprim 8 mg/kg/day) vs ceftazidime (100 mg/kg/day) + co-trimoxazole (trimethoprim 8 mg/kg/day) in the treatment of severe melioidosis was conducted at Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand, from July 1995 to September 1996. A total of 84 patients were enrolled in the study. Forty of them (48%) had culture-proven melioidosis and were randomly assigned to one of the two treatment groups, each group with 20 patients. Two cases (one in each treatment group) were excluded from the final analysis due to incomplete data. There was no significant difference in the mortality rate between the two groups-16 per cent (3/19) in the cefoperazone/sulbactam group vs 21 per cent (4/19) in the ceftazidime group (p > 0.05). Bacteriological responses of successfully treated patients were similar in both groups, and both treatment regimens were well tolerated. Cefoperazone/sulbactam + co-trimoxazole can therefore be used as an alternative treatment for severe melioidosis. However, to further support this conclusion, a study with a larger patient population is needed.engAdultAnti-Bacterial Agents --therapeutic useAnti-Infective Agents --therapeutic useCefoperazone --therapeutic useCeftazidime --therapeutic useChi-Square DistributionDouble-Blind MethodDrug Therapy, Combination --therapeutic useFemaleHumansMaleMelioidosis --drug therapyMiddle AgedProspective StudiesStatistics, NonparametricSulbactam --therapeutic useTrimethoprim-Sulfamethoxazole Combination --therapeutic useClinical Trial