Smrkovski, L LBuck, R LRodriguez, C SWooster, M TMayuga, J LRivera, D2009-05-272009-05-271982-12-01Smrkovski LL, Buck RL, Rodriguez CS, Wooster MT, Mayuga JL, Rivera D. Chloroquine and quinine resistant Plasmodium falciparum on the island of Mindoro, Philippines, 1982. The Southeast Asian Journal of Tropical Medicine and Public Health. 1982 Dec; 13(4): 551-5http://imsear.searo.who.int/handle/123456789/31078The Southeast Asian Journal of Tropical Medicine and Public Health.A field study was conducted on the island of Mindoro, Republic of the Philippines in which over 800 persons were screened for malaria and approximately 8% were found positive. The in vitro microtechnique was used to test for sensitivity to chloroquine, amodiaquine, mefloquine and quinine in 20 slide-confirmed P. falciparum cases. Sixteen of these cases were also followed for in vivo chloroquine sensitivity. Four cases showed in vitro resistance to chloroquine; 2 also showed resistance to quinine. All showed in vitro sensitivity to mefloquine and amodiaquine. The results of in vivo test were consistent with either a sensitive (S) or R-1, resistant response to chloroquine. Taken together, the in vitro and in vivo chloroquine tests indicate 4 cases of chloroquine resistance at the R1 level.engChloroquine --pharmacologyDrug ResistanceHumansPhilippinesPlasmodium falciparum --drug effectsQuinine --pharmacologyJournal Article