Sobhani, RamonaBasavaraj, AnitaGupta, AmitaBhave, Ashok SKadam, Dilip BSangle, Shashikala APrasad, Haridas BChoi, JolineJosephs, JoshuaGebo, Kelly AMorde, Shweta NBollinger, Robert CKakrani, Arjun L2007-08-132009-05-272007-08-132009-05-272007-08-13Sobhani R, Basavaraj A, Gupta A, Bhave AS, Kadam DB, Sangle SA, Prasad HB, Choi J, Josephs J, Gebo KA, Morde SN, Bollinger RC, Kakrani AL. Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India. Indian Journal of Medical Research. 2007 Aug; 126(2): 116-21http://imsear.searo.who.int/handle/123456789/19173BACKGROUND & OBJECTIVE: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine mortality and clinical characteristics of hospitalized HIV-infected individuals in a high HIV prevalence region of India. METHODS: A retrospective chart review was done of known HIV-infected adults admitted to the Medical Service of a large, public hospital in Pune, India, from January 2002 to November 2003. RESULTS: A total of 655 HIV-infected patients were identified; 489 (74.7%) were male and 4 (0.6%) were on ART. The most common illnesses reported were tuberculosis (55.8%), diarrhoea (4.2%), and alcoholic liver disease (3.7%) . The inpatient mortality was 172 (26.3%). The most common causes of death of the 172 people were tuberculosis (52.9%) and cryptococcal meningitis (7.6%). In multivariate analysis, factors associated with increased mortality were male sex (adjusted odds ratio (AOR) 1.92, 95% CI: 1.08-3.41), haemoglobin level < 7 g/dl (AOR 2.75, 95% CI:1.23-6.14), length of stay < 2 days (OR 5.78, 95%, CI: 1.82-18.4), and cryptococcal meningitis (OR 4.44, 95% CI:1.19-16.6). INTERPRETATION & CONCLUSION: In the era prior to widespread ART, a high inpatient mortality of 26 per cent was found among hospitalized HIV-infected individuals. Thus, while hospitalization is an important access and referral point for HIV care and treatment, earlier identification of HIV-infected persons must occur to ensure they will optimally benefit from the government's ART programme.engAdultAgedAged, 80 and overAnti-Retroviral Agents --therapeutic useDiarrhea --complicationsFemaleHIV Infections --complicationsHospitalizationHumansIndia --epidemiologyLiver Diseases, Alcoholic --complicationsMaleMeningitis, Cryptococcal --complicationsMiddle AgedRetrospective StudiesTuberculosis --complicationsJournal Article