Prakash, ASingh, N PMakhija, AGarg, DKubba, SAgarwal, S K2003-04-022009-05-302003-04-022009-05-302003-04-02Prakash A, Singh NP, Makhija A, Garg D, Kubba S, Agarwal SK. Mediastinitis presenting as pyrexia of unknown origin. Journal of the Association of Physicians of India. 2003 Apr; 51(): 405-7http://imsear.searo.who.int/handle/123456789/88941A 55 year old female was admitted as a case of pyrexia of unknown origin (PUO) of 2 months duration. She had developed throat ache, progressive dysphagia for both solids and liquids, dry cough and retrosternal pain for one week. Examination revealed fever, tachycardia, tachypnoea and a soft tissue warm tender, erythematous, non-fluctuant swelling in lower anterior neck with chest findings suggestive of bilateral pleural effusion. Plain X-rays of the neck and chest strengthened the clinical suspicion of cellulitis of lower neck with bilateral pleural effusion. CT scan confirmed the radiologic findings and also revealed pericardial effusion and thickening; small mediastinal lymphadenopathy and mediastinitis. Patient responded to parenteral antibiotics (ceftriaxone and metronidazole) and hydrocortisone with complete resolution in 10 days.engAnti-Bacterial Agents --therapeutic useAnti-Infective Agents --therapeutic useCeftriaxone --therapeutic useFemaleFever of Unknown Origin --etiologyHumansIndiaMediastinitis --complicationsMetronidazole --therapeutic useMiddle AgedTomography, X-Ray ComputedCase Reports