Sharma, MuditaSharma, EklavyaPrabhu, VishnudasPai, Vinitha RamanathD'souza, Jyothi MPSindhu, HarishJose, Maji2020-11-182020-11-182020-07Sharma Mudita, Sharma Eklavya, Prabhu Vishnudas, Pai Vinitha Ramanath, D'souza Jyothi MP, Sindhu Harish, Jose Maji. Salivary L-fucose as a biomarker for oral potentially malignant disorders and oral cancer. Journal of Cancer Research and Therapeutics. 2020 Jul; 16(3): 546-5500973-1482http://imsear.searo.who.int/handle/123456789/213857Background: The objective of this study was to evaluate the serum and salivary L-fucose in oral potentially malignant disorders (OPMDs) and oral cancer (OC) in order to investigate the possibility of using this as biomarker for early diagnosis. Materials and Methods: The study included 85 participants, who were grouped as control (30), OPMDs patients (25), and OC patients (30). Serum and unstimulated whole saliva were collected from participants of all groups and fucose estimation was done using spectrophotometry. The results were tabulated and analyzed statistically. Results: The mean serum L-fucose levels in normal, OPMDs, and OC group were 3.49, 19.18, and 35.75 mg/dl, respectively, while the levels of salivary L-fucose were 3.18, 7.02, and 11.66 mg/dl, respectively. A highly significant rise (P < 0.001) in serum and salivary L-fucose was observed in the study participants compared to control. Conclusions: The present study showed a significant and gradual increase in serum and salivary L-fucose from control to OPMDs to OC. From this study, we suggest that L-fucose can be used as a reliable biomarker and saliva can be used as a diagnostic fluid for screening and early detection of OCL-fucoseoral canceroral potentially malignant disorderssalivaserumSalivary L-fucose as a biomarker for oral potentially malignant disorders and oral cancerJournal ArticleIndiaDepartment of Oral Pathology and Microbiology, Geetanjali Dental and Research Institute, Geetanjali University, Udaipur, Rajasthan, IndiaDepartment of Oral and Maxillofacial Surgery, Geetanjali Dental and Research Institute, Geetanjali University, Udaipur, Rajasthan, IndiaDepartment of Oral Pathology and Microbiology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, IndiaDepartment of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, IndiaDepartment of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, Andaman and Nicobar Islands, IndiaDepartment of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, IndiaDepartment of Oral Pathology and Microbiology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, India