Agbai, E. O.Nwanegwo, C. O.Njoku, C. J.Onyebuagu, P. C.Ekezie, J.Nwafor, A. C.Eke, C. C.2020-01-022020-01-022019-04Agbai E. O., Nwanegwo C. O., Njoku C. J., Onyebuagu P. C., Ekezie J., Nwafor A. C., Eke C. C.. Tetrapleura tetraptera Extract Inhibited Luteinizing Hormone and Estrogen Secretion in Clomiphene Citrate Treated Female Wistar Albino Rats. European Journal of Medicinal Plants. 2019 Apr; 27(2): 1-6,2231-0894http://imsear.searo.who.int/handle/123456789/189476Tetrapleura tetraptera stem bark has been reported to cause inhibition of luteinizing hormone release in cultured rat pituitary cells. Hence, we investigated the effects of Tetraptera tetrapleura pod extract on follicle stimulating hormone, luteinizing hormone, cortisol, progesterone and estrogen. Thirty non-pregnant female wistar albino rats were divided into group A - D. Group A rats were used as Control. Group B rats were administered 1 mg/kg/day of clomiphene citrate orally. Group C rats were administered 200 mg/kg of extract only, whereas group D rats were administered 1 mg/kg /day of Clomiphene citrate plus 200 mg/kg of extract. At the end of 14 days experiment, group A, B and D were found in proestrus phase and group C in diestrus phase. FSH and cortisol levels remained unchanged. Group C and D rats produced significant reduction (P < 0.05) in LH and estrogen levels in prolonged proestrus and normal diestrus respectively. Progesterone level was significantly high (P < 0.05) in the group C rats. The reduced LH level could be due to the anti-estrogenic effect of extract during proestrus when LH secretion is expected to surge. But co-administration resulted in high progesterone secretion, suggesting extract may have influenced progesterone secretion in group D rats simultaneously administered with clomiphene citrate and extract. The above findings indicated that Tetrapleura tetraptera pod extracts inhibited luteinizing hormone and estrogen even when co-administered with clomiphene citrate.Tetrapleura tetrapteraclomiphene citrateestrous cycleJournal ArticleIndiaDepartment of Human Physiology, School of Basic Medical Sciences, Federal University of Technology Owerri, Imo State, Nigeria.Department of Physiology, College of Medicine, Imo State University, Owerri, Imo State, Nigeria.Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.Department of Human Physiology, School of Basic Medical Sciences, Federal University of Technology Owerri, Imo State, Nigeria.Department of Anatomy, School of Basic Medical Sciences, Federal University of Technology Owerri, Imo State, Nigeria.Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.Department of Prosthetics and Orthotics, School of Health Technology, Federal University of Technology Owerri, Imo State, Nigeria.