Datta, SGiri, ADatta, A K1996-12-012009-05-311996-12-012009-05-311996-12-01Datta S, Giri A, Datta AK. Role of hypo-osmotic sperm swelling test in assisted reproduction. Journal of the Indian Medical Association. 1996 Dec; 94(12): 440-2http://imsear.searo.who.int/handle/123456789/103893Hypo-osmotic sperm swelling (HOS) profile is found to be a better predictor of the fertilisability in those husbands possessing subnormal semen parameters. The group where husband's HOS gradings were less than 60%, no one could conceive his fertile wife even after intra-uterine insemination (IUI) for 8 times. However, in the other group where the HOS values were greater than 60%, conception were registered in 6 oligospermic and 2 asthenospermic husbands after 2 to 8 IUI amongst 22 married couples. No conception occurred in any normal coital cycle. All the pregnancies were delivered by elective caesarean section (4 females and 3 males), their birth weights were 2.705 +/- 0.425 kg. One aborted spontaneously at 10 weeks' gestation. The emerging fact in this study is where the HOS values are below 60% the male fertility is reduced, the chances of conception are trivial but fecundity is relatively fair where HOS reading is greater than 60%. It is also a no risk and high benefit method to pick and choose subfertile husbands who are likely to conceive their fertile wives by assisted reproductive techniques.engAdultFemaleHumansHypotonic SolutionsIndiaInfertility, Male --diagnosisInsemination, Artificial, HomologousMalePregnancyPrognosisSperm CountSperm-Ovum Interactions --physiologySpermatozoa --physiologyWater-Electrolyte Balance --physiologyJournal Article