Goel, AKaushal, VHooda, H SDas, B P2000-07-062009-05-292000-07-062009-05-292000-07-06Goel A, Kaushal V, Hooda HS, Das BP. Comparison of two radiation dose schedules in post mastectomy carcinoma of the breast. Indian Journal of Medical Sciences. 2000 Jul; 54(7): 278-83http://imsear.searo.who.int/handle/123456789/67188In 108 histopathologically proved breast cancer patients, after surgical treatment with modified radical mastectomy, two radiation dose schedules have been compared. Radiation therapy was given on a 60Co teletherapy machine using gent pair technique for chest wall irradiation and direct fields for lymphatic drainage areas. The patients were randomly divided into two groups (Group A and Group B). 54 patients were given external radiotherapy 40 Gy/17 F/3.2 weeks and remaining 54 patients were given 45 Gy/20 F/4 weeks. Results of treatment in Group A versus Group B were as follows; chest wall failure 5/50(10%) versus 3/54 (5.6%), axillary lymphnods failure 3/50(6%) versus 4/54(7%), distant metastasis 16/50(32%) versus 15/54(28%). Radiation reactions were almost similar in both the groups. Skin reactions were most common radiation effects [45/50 (90%) in Group A and 43/54 (79.6% in Group B]. Thus no statistically significant difference in local control and efficacy of these two radiation dose schedules was observed in postmastectomy carcinoma of the breast.engAdultAgedBreast Neoplasms --diagnosisCarcinoma --diagnosisDose-Response Relationship, RadiationFemaleHumansMastectomy --methodsMiddle AgedPrognosisRadiation DosageRadiotherapy, AdjuvantSurvival RateTreatment OutcomeClinical Trial