Nimmannitya, SThisyakorn, UHemsrichart, V2009-05-272009-05-271987-09-01Nimmannitya S, Thisyakorn U, Hemsrichart V. Dengue haemorrhagic fever with unusual manifestations. The Southeast Asian Journal of Tropical Medicine and Public Health. 1987 Sep; 18(3): 398-406http://imsear.searo.who.int/handle/123456789/33978The Southeast Asian Journal of Tropical Medicine and Public Health.A retrospective study on 18 cases of DHF presented with jaundice and neurological signs which were considered unusual manifestation of DHF reveals that the causes or contributing factors are multifactorial. Most commonly found associated conditions were prolonged shock with metabolic acidosis and severe DIC that lead to hypoxia/ischaemia and resulted in both hepatic and brain dysfunction. Gross haemorrhage in the brain was noted in 6 of the 10 fatal cases while brain oedema was noted in 3 cases. Electrolyte disturbance such as hyponatremia could be another cause of brain oedema. It is certain from this study that there is no pathological evidence of encephalitis. Hepatic dysfunction found in associated with jaundice and encephalopathy is possibly caused by toxic substances, drugs and/or associated with underlying liver conditions. Reye's or Reye's-like syndrome was postulated in one case.engBrain Diseases --etiologyChildChild, PreschoolConsciousness Disorders --etiologyDengue --complicationsFemaleHumansInfantLiver Diseases --etiologyMaleSeizures --etiologyJournal Article