Mishra, SNarang, RSharma, MChopra, ASeth, SRamamurthy, SPrabhakaran, DGoswami, K CTalwar, K KManchanda, S CBahl, V K2001-03-292009-05-272001-03-292009-05-272001-03-29Mishra S, Narang R, Sharma M, Chopra A, Seth S, Ramamurthy S, Prabhakaran D, Goswami KC, Talwar KK, Manchanda SC, Bahl VK. Percutaneous transseptal mitral commissurotomy in pregnant women with critical mitral stenosis. Indian Heart Journal. 2001 Mar-Apr; 53(2): 192-6http://imsear.searo.who.int/handle/123456789/5519BACKGROUND: Percutaneous transseptal mitral commissurotomy has been successfully performed in selected pregnant patients with severe symptomatic mitral stenosis. Its safety and efficacy needs to be evaluated in a large number of cases. METHODS AND RESULTS: Percutaneous transseptal mitral commissurotomy was performed in 85 severely symptomatic (New York Heart Association functional class III or IV) pregnant women aged 22.7+/-4.1 years (range 18-39 years) with critical mitral stenosis at 24.8+/-4.7 weeks (range 20-34 weeks) of gestation. Percutaneous valvotomy was performed using a flow-guided Inoue balloon in all the patients. The procedure was considered successful in 80 (94%) patients. The hemodynamic mean end-diastolic gradient decreased from 26.7+/-6.8 mm Hg (range 16-35 mmHg) to 4.5+/-3.8 mmHg (range 0-14 mmHg) (p<0.001). The mean diastolic gradient decreased from 29.1+/-9.1 mmHg (range 18-38 mmHg) to 7.2+/-4.1 mmHg (range 4.1-18 mmHg) (p<0.001). The mean mitral valve area assessed by echocardiography increased from 0.75+/-0.5 cm2 (range 0.4-1.0 cm2) to 2.0+/-0.5 (range 1.0-2.7 cm2) (p<0.001). The mean fluoroscopy time was 3.6+/-3.2 minutes. The results of the mitral valvotomy were considered suboptimal in 4 patients. Mitral regurgitation increased by 1 grade in 16 patients and more than 2 grades in 2 patients. One patient developed pericardial tamponade during the procedure and was managed by catheter drainage. Percutaneous mitral valve dilatation was then successfully performed in this patient. No fetal abortion occurred after the procedure. CONCLUSIONS: The results of this study indicate that percutaneous transseptal mitral commissurotomy is a safe and effective procedure for severe symptomatic mitral stenosis in pregnancy.engAdolescentAdultBalloon Dilatation --methodsEchocardiography --methodsFemaleFollow-Up StudiesGestational AgeHeart Function TestsHemodynamics --physiologyHumansIndiaMitral Valve Stenosis --therapyPregnancyPregnancy Complications, Cardiovascular --therapyPregnancy OutcomeProbabilitySeverity of Illness IndexTreatment OutcomeUltrasonography, Doppler --methodsUltrasonography, Prenatal --methodsClinical Trial