Dhochak, NitinJat, Kana RamSoni, Kapil DevSingh, YudhyavirAggarwa, RichaLodha, RakeshTrikha, AnjanKabra, Sushil K.2023-08-192023-08-192022-04Dhochak Nitin, Jat Kana Ram, Soni Kapil Dev, Singh Yudhyavir, Aggarwa Richa, Lodha Rakesh, Trikha Anjan, Kabra Sushil K.. Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis. Indian Journal of Pediatrics. 2022 Apr; 89(4): 404–4060973-76930019-5456http://imsear.searo.who.int/handle/123456789/223712Children with cystic fbrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with signifcant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2–related severe lower respiratory infection within a period of 2 mo, requiring high-fow nasal oxygen support. Both children had 3rd pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding.Cystic fibrosisSARS-CoV-2Poor lung healthProlonged viral sheddingJournal ArticleIndiaDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India