Ksheerasagar, VKNarapogu, VBgheal, PChaganti, N.2023-06-272023-06-272023-03Ksheerasagar VK, Narapogu V, Bgheal P, Chaganti N.. Evaluation of ethanolic extract of leaves of Abutilon indicum on carrageenan-induced rat paw edema. National Journal of Physiology, Pharmacy and Pharmacology. 2023 Mar; 13(3): 607-6102231-32062320-4672http://imsear.searo.who.int/handle/123456789/217975Background: Inflammation is described as a localized physical condition whereat part of the body becomes swollen, reddened, hot, and consistently painful, largely as a response to injury or infection. Aim and Objectives: The current study is designed to study the Abutilon indicum for its anti-inflammatory activity in albino rats-induced paw edema by carrageenan. Materials and Methods: Randomly 30 albino rats from both sexes were taken and divided into five groups, six in each. Normal saline 25 mL/kg (control), diclofenac 9 mg/kg (standard), and three different doses of plant extract (EEAI) such as 250, 500, and 1000 mg/kg (3 test groups) were given in respective groups, after 1-h injection of 0.1 mL of 0.2% carrageenan solution into the sub plantar region of the right hind paw. At 0 h, after 1, 2, and 3 h, paw edema volume was measured by mercury displacement method using plethysmograph. The percentage of edema inhibition was measured in all five groups. Results: The percentage of edema inhibition for EEAI 500 mg/kg was 6.20%, 17.8%, and 26.72% after 1st, 2nd and 3rd h respectively and for EEAI 1000 mg/kg was 8.26%, 20.7%, 31.61% after 1st, 2nd, and 3rd h, respectively. Significant edema inhibition was observed after 2nd and 3rd h of drug administration (P < 0.05) in both groups treated with EEAI 500 and 1000 mg/kg. Conclusion: Ethanolic extract of A. indicum had shown dose dependent anti-inflammatory activity.CarrageenanDiclofenacInflammationAbutilon IndicumJournal ArticleIndiaDepartment of Pharmacology, RVM Institute of Medical Sciences and Research Center, Telangana, IndiaDepartment of Pharmacology, Government Medical College, Budaun, Uttar Pradesh, IndiaDepartment of Pharmacology, Autonomous State Medical College, Firozabad, Uttar Pradesh, IndiaDepartment of Pharmacology, Chalmeda Ananda Rao Institute of Medical Sciences, Karimnagar, Telangana, India