Brockelman, C RThanomsub, BBhisutthibhand, J2009-05-272009-05-271989-09-01Brockelman CR, Thanomsub B, Bhisutthibhand J. Mefloquine sulfadoxine pyrimethamine (MSP) combination delays in vitro emergence of mefloquine resistance in multiple drug resistant Plasmodium falciparum. The Southeast Asian Journal of Tropical Medicine and Public Health. 1989 Sep; 20(3): 371-8http://imsear.searo.who.int/handle/123456789/36202The Southeast Asian Journal of Tropical Medicine and Public Health.Sulfadoxine-pyrimethamine-resistant and chloroquine resistant, but mefloquine sensitive (MIC 5 x 10(-9] isolates of Plasmodium falciparum were used to study the emergence of mefloquine resistance. The continuously cultured isolates which were exposed intermittantly to varying concentrations of mefloquine alone became insensitive to the drug at 1 x 10(-7) M after 12 months, whereas the culture line exposed to the combination of mefloquine, sulfadoxine and pyrimethamine became only slightly insensitive to mefloquine (MIC 2 x 10(-8]. Thus, the efficacy of mefloquine may be prolonged through use in combination with sulfadoxine-pyrimethamine.engAnimalsDrug ResistanceDrug Therapy, CombinationHumansMefloquine --therapeutic useParasitology --methodsPlasmodium falciparum --drug effectsPyrimethamine --therapeutic useSulfadoxine --therapeutic useSulfanilamides --therapeutic useThailandTime FactorsJournal Article