Balakrishnan, SBhargava, V KPandhi, P2009-05-282009-05-281999-04-21Balakrishnan S, Bhargava VK, Pandhi P. Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. Indian Journal of Experimental Biology. 1999 Apr; 37(4): 340-3http://imsear.searo.who.int/handle/123456789/56850The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate. The median effective dose [ED50] of valproate, nimodipine and nitrendipine were initially determined. All the 3 drugs were injected i.p. 30 min before the induction of seizures. Seizures were induced by PTZ 85 mg/kg i.p., and subsequently the effect of combining ED50 doses of nimodipine and nitrendipine with ED50 dose of valproate was evaluated. ED50 of valproate and nitrendipine were 129 and 2.5 mg/kg respectively. ED50 of nimodipine could not be established since a dose-response relationship was not obtained. Hence, for the purpose of combination studies, 4 mg/kg of nimodipine was used. Both nimodipine (4 mg/kg) and nitrendipine (2.5 mg/kg) decreased the ED50 of valproate from 129 to 40 mg/kg. Both nimodipine and nitrendipine potentiate the activity of valproate against PTZ induced seizures and can be considered as potential adjuvant anticonvulsants which merit further study.engAnimalsAnticonvulsants --administration & dosageDose-Response Relationship, DrugDrug Therapy, CombinationFemaleMaleNimodipine --administration & dosageNitrendipine --administration & dosagePentylenetetrazole --toxicityRatsSeizures --chemically inducedValproic Acid --administration & dosageJournal Article