Gupta, SSrivastava, J KJain, M KKatiyar, J CSingh, JBhakuni, D S2009-05-282009-05-281991-07-01Gupta S, Srivastava JK, Jain MK, Katiyar JC, Singh J, Bhakuni DS. Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites. Indian Journal of Experimental Biology. 1991 Jul; 29(7): 645-8http://imsear.searo.who.int/handle/123456789/62406Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.engAncylostoma --drug effectsAnimalsAnthelmintics --pharmacologyBeetlesHymenolepis --drug effectsLarvaMebendazole --analogs & derivativesNippostrongylus --drug effectsPraziquantel --pharmacologyRodentiaComparative Study