Bhattacharya, NMahajan, SSharma, K N1991-04-012009-06-011991-04-012009-06-011991-04-01Bhattacharya N, Mahajan S, Sharma KN. Morphine-induced modulation of sciatic nerve stimulation evoked blood pressure responses. Indian Journal of Physiology and Pharmacology. 1991 Apr; 35(2): 125-9http://imsear.searo.who.int/handle/123456789/108508Effect of i.v. morphine (1-2 mg/kg) on blood pressure changes evoked by sciatic nerve stimulation (SNS) were studied in chloralose anaesthetised cats. SNS gave a depressor, pressor or a biphasic BP response generally linked to the parameters of stimulation. Morphine produced marked attenuation of depressor and some facilitation of pressor response, suggesting a possible reciprocal relationship between depressor and pressor responses. Depressor response has been correlated with deep tissue or visceral pain mediated through A delta fibres and pressor response to cutaneous nociception involving C fibres or non nociceptive input via group II fibres. Involvement of medullary regions in differential modulation of these depressor and pressor response has been suggested.engAnesthesiaAnimalsBlood Pressure --drug effectsCatsMorphine --pharmacologyNociceptors --drug effectsSciatic Nerve --drug effectsJournal Article