Bagherian, AliAsadikaram, Gholamreza2013-03-262013-03-262012-09Bagherian Ali, Asadikaram Gholamreza. Comparison of some salivary characteristics between children with and without early childhood caries. Indian Journal of Dental Research. 2012 Sept-Oct; 23(5): 628-632.http://imsear.searo.who.int/handle/123456789/145795Background and Aim: Early childhood caries (ECC) is one of the most common chronic childhood diseases. Saliva as a host factor plays an essential role in maintaining the integrity of oral structures. The aim of the present study was to compare resting salivary pH, buffering capacity, and secretory immunoglobulin A (sIgA), calcium, and phosphate concentrations between children with and without ECC. Materials and Methods: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group and 45 in caries-free group) were taken with Scully method. The pH and buffering capacity were determined by pH meter. sIgA, calcium, and phosphate concentrations were quantitated with ELISA, CPC photometric, and phosphomolybdate/UV methods. Results: The mean resting salivary pH was significantly higher among children without ECC and the buffering capacity was significantly better among this group (P = 0.002). The mean sIgA concentration was significantly higher among the ECC group (P = 0.015). There were no statistically significant differences between calcium and phosphate concentrations between the two groups. Conclusion: The higher mean resting salivary pH and better buffering capacity found in children without ECC are probably the contributing factors that protect against caries development; but further studies are needed to understand the effects of saliva and its characteristics and components on ECC.enBuffer capacitycalciumdental cariessalivaBuffersCalcium --analysisChild, PreschoolDental Caries --epidemiologyEnzyme-Linked Immunosorbent AssayHumansHydrogen-Ion ConcentrationImmunoglobulin A, Secretory --analysisPhosphates --analysisSaliva --analysisSaliva --chemistrySaliva --physiologyArticle