Thaw ZinYe ThweTin ShweThida HmunNwe Nwe YinThaung Hla2009-06-302009-06-301995-08-011995-08-01Thaw Zin, Ye Thwe, Tin Shwe, Thida Hmun, Nwe Nwe Yin, Thaung Hla. Pharmacokinetics of mefloquine in uncomplicated plasmodium falciparum malaria patients in Myanmar. Myanmar Health Sciences Research Journal. 1995; 7(2): 53-58http://imsear.searo.who.int/handle/123456789/126808With the aim to study the pharmacokinetic basis underlying the therapeutic outcome of mefloquine in malaria patients, a single oral dose of 1000 mg mefloquine hydrochloride (Mepha) was administered to 24 patients with acute uncomplicated falciparum malaria and 10 healthy volunteers and was followed-up till day 42. The drug serum levels at various time intervals were analysed by a Waters HPLC and the pharmacokinetic profile studied. The study shows that although Myanmar malaria patients had a slower rate of absorption (T1/2ab = 6.38 + 0.60 hour; Tmax =1.31 + 0.12 days), the peak serum level reached was much higher (Cmax = 2.24 + 0.05 ug/ml) than those of the westerners.Plasmodium FalciparumMalaria, FalciparumMefloquine-pharmacokineticsMyanmar