Das, SPrabhakar, B R1997-10-282009-05-291997-10-282009-05-291997-10-28Das S, Prabhakar BR. Acute myelofibrosis. Indian Journal of Pathology & Microbiology. 1997 Oct; 40(4): 527-30http://imsear.searo.who.int/handle/123456789/74499Acute myelofibrosis is a rare disorder. Five such cases have been diagnosed out of 3,149 Bone Marrow (B.M) Aspirations and Trephine Biopsies studied over a period of eight and a half years. Four out of five patients were males and the other female. Their age ranged from 14-71 years. Neither splenomegaly not red cell poikilocytosis (tear drop cells) were prominant features. B.M. trephine biopsy showed increase of atypical megakaryocytes/megakaryoblasts and marked fibrosis. There was rapid downhill clinical course of the disease in all cases.engAcute DiseaseAdolescentAdultAgedBiopsy, NeedleBone Marrow --pathologyBone Marrow Cells --pathologyFemaleFibrosisFollow-Up StudiesHumansMaleMegakaryocytes --pathologyPrimary Myelofibrosis --pathologyJournal Article