Abdel-Aziz, A FEl-Saeed, AfafEL-Dahshan, KhaledEbead, Basma AL-Sayed2016-03-042016-03-042014-03-11Abdel-Aziz A F, El-Saeed Afaf, El-Dahshan Khaled, Ebead Basma Al-Sayed. Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients. British Journal of Medicine and Medical Research. 2014 Mar; 4(8): 1763-1771.http://imsear.searo.who.int/handle/123456789/175076Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are associated with ESRD as risk factors in several studies. In this study, we investigated the association between ACE I/D gene polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD genotype were significantly increased, while frequencies of I allele and ID genotype were significantly decreased in the ESRD patients when compared with the control subjects (P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95% CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with ESRD as risk factors for ESRD in the Egyptian population.enAngiotensin-I-converting enzyme (I/D) polymorphismend stage renal diseaseArticle