Thulluru, AshokAnuradha, K. C.kumar, K. SaravanaNawaz, MahammedKumar, Ch. S. PhaniMohan, K. Siva Jagan2020-09-242020-09-242019-06Thulluru Ashok, Anuradha K. C., kumar K. Saravana, Nawaz Mahammed, Kumar Ch. S. Phani, Mohan K. Siva Jagan. Colon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilization. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Jun; 8(3): 12-192282-02382393-932Xhttp://imsear.searo.who.int/handle/123456789/203820Albendazole (AZ) is a drug used for the treatment of gastrointestinal nematode infections. Phase solubility study was performed to investigate the optimized ratio of AZ: β-cyclodextrin (β-CD) solid dispersion (SD). Increase in the solubility of optimized AZ: β-CD SD was further enhanced by addition sodium lauryl sulfate (SLS) in different ratios was studied. Matrix tablets of the optimized ratio of AZ: β-CD SD with SLS and various proportions (10%, 15%, and 20%) of guar gum (GG). xanthan gum (XG) and pectin (PT) were prepared by non-aqueous wet granulation with PVP K30. Standard calibration curve for AZ was performed in three buffers like 0.1 N HCl, pH 6.8 phosphate buffer solution (PBS) and pH 7.4 PBS and absorbance were measured at 295 nm. Tablets were evaluated for various physical characteristics such as thickness, hardness, and drug content uniformity. The matrix tablets were subjected to in vitro drug release studies in 0.1 N HCl (2 h), pH 6.8 PBS (3 h) and pH 7.4 PBS (19 h) with and without rat caecal content medium. Formulation F9 shows 70.65% and 95.62% of AZ in with and without rat caecal content media respectively is selected as optimized one. Optimized formulation F9 passed the test for stability up to 3 months as per ICH guidelines.Albendazole?-Cyclodextrinsodium lauryl sulfateguar gum. xanthan gumpectinJournal ArticleIndiaDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy , A. Rangampet, Tirupati-517 102, Chittoor (Dist.), IndiaDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), IndiaDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), IndiaDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517 102, Chittoor (Dist.), IndiaDepartment of Pharmaceutics, Adarsa College of Pharmacy, G. Kothapalli-533 285, Gokavaram (Md.), E.G. (Dist.), IndiaDepartment of Pharmaceutics, Sree Vidyanikethan College of Pharmacy , A. Rangampet, Tirupati-517 102, Chittoor (Dist.), India