Kshirsagar, Nilima AMunshi, RenukaBavdekar, Sandeep BSaxena, Rohit2023-08-252023-08-252022-10Kshirsagar Nilima A, Munshi Renuka, Bavdekar Sandeep B, Saxena Rohit. Irrational ophthalmic fixed-dose combinations for dry eye syndrome. Indian Journal of Ophthalmology. 2022 Oct; 70(10): 3687-36891998-36890301-4738http://imsear.searo.who.int/handle/123456789/224640Dry eye syndrome (DES) is a common disorder with rising incidence due to increased use of digital devices. While multiple treatment options are available, some are not efficacious or sometimes even safe for use in DES. This is particularly true for Fixed Dose Combinations (FDCs) that may contain ingredients having no rational for their use or may actually be harmful. Various committees appointed by the Government have reviewed several FDCs marketed in India and found some of them to be irrational and recommended for their removal. This paper discusses the contents of some of these FDCs marketed for DES with an aim to ensure that prescribers are mindful of their ingredients and whether there is adequate data about their efficacy and safety and prescribe them only if they consider them necessary for managing the patient.Fixed?dose combinationsFDCsDrug Technical Advisory Board [DTAB]Dry eyeeyedropsirrational ophthalmic dropsJournal ArticleIndiaDepartment of Clinical Pharmacology, Emeritus Scientist, ICMR, New Delhi, IndiaDepartment of Clinical Pharmacology, TN Medical College and BYL Nair Hospital, Mumbai, Maharashtra, IndiaDepartment of Clinical Pharmacology, Surya Children’s Hospital, Mumbai, Maharashtra, IndiaPediatric Ophthalmology and Strabismus Services, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India