Ray, KausikHazra, RimiDebnath, Pratip KrGuha, Debjani2009-05-282009-05-282004-06-21Ray K, Hazra R, Debnath PK, Guha D. Role of 5-hydroxytryptamine in Moringa oleifera induced potentiation of pentobarbitone hypnosis in albino rats. Indian Journal of Experimental Biology. 2004 Jun; 42(6): 632-5http://imsear.searo.who.int/handle/123456789/58833The role of 5-hydroxytryptamine (5-HT) in pentobarbitone (PB) sleeping time, gross behaviour, electrical activity of the brain and serum 5-HT level was studied in Holtzman strain adult albino rats following treatment with M. oleifera (MO). MO (350mg/kg) caused inhibition of awareness, touch response, motor activity, righting reflex, and grip strength. It significantly increased the PB sleeping time, serum 5-HT level (P<0.001) and alpha-wave activity. These observations indicate that the aqueous extract of MO potentiated PB induced sleeping time and increased the alpha-wave activity through 5-HT.engAnimalsBehavior, Animal --drug effectsBrain --metabolismDose-Response Relationship, DrugElectroencephalographyFemaleFree Radical Scavengers --pharmacologyHypnosisMalePentobarbital --pharmacologyRatsSerotonin --bloodSleepTime FactorsJournal Article