Trinavarat, AdisakAtchaneeyasakul, La-OngsriSurachatkumtonekul, ThammanoonKosrirukvongs, Panida2009-05-272009-05-272003-02-08Trinavarat A, Atchaneeyasakul LO, Surachatkumtonekul T, Kosrirukvongs P. Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification. Journal of the Medical Association of Thailand. 2003 Feb; 86(2): 143-50http://imsear.searo.who.int/handle/123456789/44651Chotmaihet Thangphaet.AIMS: To compare the efficacy and ocular adverse effects of topical prednisolone acetate, ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsification. METHOD: One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly: visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms. RESULTS: The number of eyes with a minimal amount of cells in the anterior chamber in the ketorolac group was less than the prednisolone group on day 7 (11:20, p = 0.008) and day 14 (23:31, p = 0.015), and than fluorometholone group on day 7 (11:21, p = 0.011). Intraocular pressure in the prednisolone group was higher than the ketorolac group on day 21 (14.6:12.2 mmHg, p = 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group. CONCLUSION: All 3 drugs were effective in reducing post-operative inflammation. The efficacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.engAdministration, TopicalAdultAgedAnalysis of VarianceAnti-Inflammatory Agents --administration & dosageChi-Square DistributionDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorometholone --administration & dosageFollow-Up StudiesHumansInflammation --prevention & controlIntraocular Pressure --drug effectsKetorolac Tromethamine --administration & dosageMaleMiddle AgedPhacoemulsification --adverse effectsPostoperative Complications --prevention & controlPrednisoloneProbabilityProspective StudiesReference ValuesRisk AssessmentSingle-Blind MethodTreatment OutcomeClinical Trial