Sharma, GNain, PSSethi, PAhuja, ASharma, S2020-04-102020-04-102019-04Sharma G, Nain PS, Sethi P, Ahuja A, Sharma S. Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals. Indian Journal of Medical Research. 2019 Apr; 149(4): 544-5470971-59160975-9174http://imsear.searo.who.int/handle/123456789/195851Background & objectives: Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients. Methods: The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m[2]] and severely obese patients (BMI >35/kg/m[2]) who underwent sleeve gastrectomy. The patients were followed up for six months. Weight loss parameters and plasma ghrelin levels were assessed pre- and postoperatively. Results: A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen. Interpretation & conclusions: These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.Ghrelinobesesleeve gastrectomyweight lossJournal ArticleIndiaDepartment of Physiology, Dayanand Medical College & Hospital, Ludhiana, IndiaDepartment of Surgery, Dayanand Medical College & Hospital, Ludhiana, IndiaDepartment of Gastrointestinal Surgery, Amrita Institute of Medical Sciences & Research, Kochi, IndiaDepartment of Community Medicine, Dayanand Medical College & Hospital, Ludhiana, India