Sharma, GauravKaur, GurvinderMehra, Narinder2012-03-272012-03-272011-12Sharma Gaurav, Kaur Gurvinder, Mehra Narinder. Genetic correlates influencing immunopathogenesis of HIV infection. Indian Journal of Medical Research. 2011 Dec; 134(6): 749-768.http://imsear.searo.who.int/handle/123456789/137339Variability to HIV infection, its progression as well as responsiveness to antiretroviral therapy (ART) is observed among individuals including viraemia controllers or exposed uninfected, rapid versus slow progressors and ART responders compared to non responders. This differential responsiveness/ vulnerability to HIV-1 is governed by multiple host genetic factors that include HLA, cytokines, chemokines, their receptors and others. This review highlights the influence of these genetic factors on HIV/AIDS outcome; however, in India, the information in this area is very limited and most of these genetic studies have been conducted in Caucasian and South African populations. Considering, the population specific differences in the frequencies of protective or susceptibility favouring alleles and their influence on the disease outcome, it is of utmost importance to strengthen ongoing efforts towards defining largely unknown genetic propensity in Indian population, particularly by recruitment of large cohorts of well categorized exposed uninfected individuals, rapid, long term non progressors and elite viraemic controllers. Multi-parametric analysis of these potentially interactive immunogenetic variables in these cohorts may help to define potential targets for diagnostics and therapy in a population specific manner.enChemokinescytokinescladesexposed uninfected individualsgenetic correlatesgenetic variantsHIVHIV/AIDSHLAimmunopathogenesisrapid & slow progressorsviraemia controllersChemokines --geneticsChemokines --immunologyCytokines --geneticsCytokines --immunologyGenetic Predisposition to Disease --ethnologyGenetic Predisposition to Disease --geneticsGenetic VariationHIV Infections --drug therapyHIV Infections --epidemiologyHIV Infections --geneticsHIV Infections --immunologyHIV Infections --physiopathologyHIV-1 --geneticsHIV-1 --immunologyHIV-1 --pathogenicityHLA Antigens --geneticsHLA Antigens --immunologyHaplotypes --geneticsHumansIndia --epidemiologyArticle