Krishnamurthy, NBalakumar, BThombre, D P1992-10-012009-06-011992-10-012009-06-011992-10-01Krishnamurthy N, Balakumar B, Thombre DP. Effects of undernutrition and sex difference on skeletal muscle function in young rats. Indian Journal of Physiology and Pharmacology. 1992 Oct; 36(4): 234-8http://imsear.searo.who.int/handle/123456789/107746The effects of undernutrition and sex difference on skeletal muscle contractile characteristics were studied in young albino rats. The skeletal muscle (gastrocnemius) of 8 week old pups with only one-third normal food intake (undernourished group = UN group; n = 18), as compared to free fed pups (control group = cont. group; n = 16), showed prolongation of contraction time (23.6 +/- 1.0 Vs 20.9 +/- 0.8 msec, Mean +/- SE, P < 0.05) and relaxation time (31.5 +/- 1.8 Vs 22.9 +/- 1.1 msec, P < 0.001) and retention of contraction force and endurance time. In 18 week old rats the effects of sex difference in females (n = 10), as compared to males (n = 10) were prolongation of contraction time in gastrocnemius (32.2 +/- 1.5 Vs 27.8 +/- 1.5 msec, P < 0.05), less force production in gastrocnemius (668.9 +/- 48.0 Vs 895.4 +/- 93.3 g, P < 0.05) and extensor digitorum longus (20.1 +/- 3.3 Vs 29.9 +/- 2.5 g, P < 0.05) and shorter endurance time (160.8 +/- 10.2 Vs 187.2 +/- 7.1 sec, P < 0.05) in soleus. Thus, it is concluded that early undernutrition has prolonged the contraction and relaxation times of the skeletal muscles and the effect of sex difference in the early adulthood was different in different skeletal muscles.engAnimalsBody Weight --physiologyDeficiency Diseases --physiopathologyFemaleFood Deprivation --physiologyMaleMuscle Contraction --physiologyMuscles --physiologyNutritional Status --physiologyRatsRats, WistarSex CharacteristicsComparative Study