Bungorn SripanidkulchaiNiramai FangkratokJintana JunlatatKittisak Sripanidkulchai2011-02-202011-02-202010-03-122010-03-12Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 4 No.2 July-December 2008; 104-112http://imsear.searo.who.int/handle/123456789/130678This study aimed to investigate the antioxidative activity and antimutagenicity of six extracts of three plants in Annonaceae, collected from Khok Phutaka area, Amphur Phuwiang, Khon Kaen. The results showed the strong antioxidative activities of the extracts from stem-root of Ellipeiopsis cherrevensis and leaf of Polyalthia evecta with EC₅₀ at 14.3 and 14.7 \µg/ml, respectively. The other extracts with relative order of activity were leaf of E. cherrevensis \> leaf of P. debilis \> stem-root of P. evecta \> stem-root of P. debilis (EC₅₀ = 17.9, 22.8, 46.3 and 177.9 \µg/ml, respectively). The plant total phenolic contents are well correlated with their antioxidative activities. For pre-incubation bacterial mutation test, the extracts from leaf and stem-root of E. cherrevensis showed mutagenic effect on Salmonella typhimurium TA98 and TA100 in the absence of S-9 mix. Whereas in the presence of S-9 mix, the mutagenicity was found in the extracts from leaf of E. cherrevensis, leaf and stem-root of P. debilis and leaf of P. evecta. The antimutagenicity was detected in both TA98 and TA100 in all extracts in the presence of S-9 mix. In contrast, in the absence of S-9 mix only the extracts from stem-root and leaf of P. debilis; and leaf of P. evecta showed the antimutagenicity to TA98. Therefore, these three plants are interesting to be further studied on their anticancer activity.en-USIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานOriginal Articles