Janakiram, Madhan Kumar SoutalluSugavasi, RajuKommanda, Radhakrishna ShettyGovindarajoo, ParthibanMani, Muthuvel2025-05-092025-05-092024-09Janakiram Madhan Kumar Soutallu, Sugavasi Raju, Kommanda Radhakrishna Shetty, Govindarajoo Parthiban, Mani Muthuvel . Histological and Immunohistochemical Study of the Beta Cells In Streptozotocin Induced Diabetic Rats Treated with Cynodon Dactylon Aqueous Extract . International Journal of Anatomy and Research. 2024 Sep; 12(3): 8996-90022321-42872321-8967https://imsear.searo.who.int/handle/123456789/243185Background: Diabetes mellitus is a chronic metabolic disorder that affects human body in terms of physical, psychological and social health. Traditional medicines have been widely used in treatment of diabetes and its complications. After administrating the aqueous extract of Cynodon dactylon in streptozotocin induced diabetic rats, we evaluated the histological and immunohistochemical effects of the ? – cells in the pancreatic islets. Objectives: The objective of the present study is to investigate the antidiabetic effect of Cynodon dactylon aqueous extract in ? – cells of islets, against streptozotocin induced diabetic rats. Materials and Methods: In this study adult male albino rats were used. Aqueous extract of Cynodon dactylon (500 mg/kg.bw/day) administered orally for 45 days. At the end of experimental period, animals were sacrificed, pancreas was isolated and processed for histological and immunohistochemical analysis. Results: The pancreas of Cynodon dactylon aqueous extract treated diabetic rats showed improved islet morphology; and the pancreatic islets of the Cynodon dactylon aqueous extract treated diabetic rats showed consistent elevation in the insulin levels from the ? – cells. Therefore, the antidiabetic activity of Cynodon dactylon aqueous extract might be due to the compounds present in the Cynodon dactylon aqueous extract which stimulate the insulin secretion and protect the intact functional ? – cells from streptozotocin induced destruction. Conclusion: Cynodon dactylon aqueous extract increased the insulin secreting ? – cells in the pancreatic islets and protecting the intact ? – cells from oxidative damage.Cynodon dactylonstreptozotocinPancreatic isletsoxidative stressJournal ArticleIndiaAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, MalaysiaAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, MalaysiaAssociate Professor, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, MalaysiaSenior Lecturer, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, MalaysiaSenior Lecturer, Department of Anatomy, Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia