Kalra, AChaturvedi, NVashishtha, V MDube, K NKalra, K1992-08-012009-05-271992-08-012009-05-271992-08-01Kalra A, Chaturvedi N, Vashishtha VM, Dube KN, Kalra K. Per rectal diazepam therapy in convulsive disorders. Indian Pediatrics. 1992 Aug; 29(8): 975-8http://imsear.searo.who.int/handle/123456789/8552One hundred and twenty children with persistent convulsions (lasting > or = 10 min) were treated with per rectal diazepam (dosage: 0.2 to 0.7 mg/kg/dose). Another group of 100 age matched children with convulsions, along with those who did not respond to rectal therapy were given intravenous diazepam in a dosage of 0.2 to 0.3 mg/kg/dose. Rectal treatment was effective in 80.83% cases while intravenous diazepam was effective in 90% cases which is statistically just significant (p < 0.05). No significant difference was observed in the efficacy of two routes of administration in controlling convulsions of different clinical types and various etiological groups (p < 0.05), except for primary generalized type where intravenous route was more effective than the rectal one (p < 0.05). No significant side-effect was observed with rectal therapy. Among the 23 (19.17%) children in whom rectal therapy failed, 12 (10%) responded to intravenous diazepam while the remaining 11 (9.17%) cases were resistant to both routes of administration.engAdministration, RectalChildChild, PreschoolDiazepam --administration & dosageFemaleHumansInfantInfant, NewbornInjections, IntravenousMaleSeizures --drug therapyTreatment OutcomeJournal Article