Gupta, Sanjeev KSharma, MonicaTyagi, SeemaPati, Hara P2012-10-122012-10-122011-07Gupta Sanjeev K, Sharma Monica, Tyagi Seema, Pati Hara P. Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 609-611.http://imsear.searo.who.int/handle/123456789/142058Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)- high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.enHbShemoglobinopathythalassemia majortransfusionBlood Transfusion --adverse effectsChild, PreschoolChromatography, High Pressure LiquidHemoglobinopathies --diagnosisHemoglobinopathies --pathologyHemoglobins --chemistryHumansInfantMalebeta-Thalassemia --complicationsbeta-Thalassemia --therapyArticle