Unnikrishnan, RDas, RJaydip, RSudhakaran, CMohan, V2012-12-032012-12-032009-02Unnikrishnan R, Das R, Jaydip R, Sudhakaran C, Mohan V. Unexpected and abnormally low HDL cholesterol levels on combination hypolipidemic therapy. Journal of the Association of Physicians of India. 2009 Feb; 57(): 180-181.http://imsear.searo.who.int/handle/123456789/143546In general, Indians have low HDL cholesterol levels. Fenofibrate, a drug widely used in the treatment of hypertriglyceridemia, usually also increases HDL cholesterol. There have been a few reports in the literature of a paradoxical decrease in serum HDL-cholesterol in patients treated with fenofibrate, either alone or in combination with a statin. We report three cases of paradoxical decrease in serum HDL- cholesterol in type 2 diabetic patients treated with a statin-fenofibrate combination. ©enCholesterol, HDL --bloodDiabetes Mellitus, Type 2 --bloodDiabetes Mellitus, Type 2 --complicationsDiabetes Mellitus, Type 2 --therapyDrug Therapy, CombinationDyslipidemias --bloodDyslipidemias --complicationsDyslipidemias --drug therapyFenofibrate --administration & dosageHeptanoic Acids --administration & dosageHumansHypolipidemic Agents --administration & dosage*MaleMiddle AgedPyrroles --administration & dosageArticle