Mannoor, M KaiissarVanisaveth, ViengxayKeokhamphavanh, BoualyToma, HiromuWatanabe, HisamiKobayashi, JunHatabu, ToshimitsuTaguchi, NaoHongvangthong, BousyPhetsouvanh, RattanaxayPhompida, SamlaneKano, ShigeyukiSato, Yoshiya2009-05-272009-05-272005-09-28Mannoor MK, Vanisaveth V, Keokhamphavanh B, Toma H, Watanabe H, Kobayashi J, Hatabu T, Taguchi N, Hongvangthong B, Phetsouvanh R, Phompida S, Kano S, Sato Y. Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Sep; 36(5): 1092-5http://imsear.searo.who.int/handle/123456789/30754The Southeast Asian Journal of Tropical Medicine and Public Health.A 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria.engAdolescentAdultChildChild, PreschoolDrug Therapy, CombinationFemaleHumansLaosMalaria, Falciparum --drug therapyMaleMiddle AgedPyrimethamine --administration & dosageSulfadoxine --administration & dosageTreatment OutcomeJournal Article