Kaur, ManmeetTiwana, Kanwardeep KaurNiborhia, SaritaArora, HobinderKaur, Arshdeep2019-11-252019-11-252018-08Kaur Manmeet, Tiwana Kanwardeep Kaur, Niborhia Sarita, Arora Hobinder, Kaur Arshdeep. Histopathological Spectrum Of Oral Lesions In A Tertiary Care Hospital. International Journal of Scientific Research. 2018 Aug; 7(8): 47-492277-8179http://imsear.searo.who.int/handle/123456789/185231Background: Evaluation of thrombocytopenia involves a meticulous approach in which complete clinical history, clinical examination, complete hemogram and bone marrow aspiration if indicated, are included. The various platelet indices produced by the automated analysers such as, Mean platelet volume (MPV), Platelet distribution width (PDW), Plateletcrit (PCT) and Large cell ratio (LCR) can be used to distinguish the underlying etiology of thrombocytopenia. Methods: Total of seventy three thrombocytopenic patients <14 years with proper clinic-hematological work up were included in the study. The results were compared by manual examination of the peripheral blood smear. Results: Patients were grouped based on the mechanism- Peripheral destruction 54 (73.9%), Hypoproduction 10 (13.6%), Hypersplenism 9 (12.3%). There was a linear correlation between the platelet count and all the platelet derived indices (MPV, PDW, PCT, LCR) in the patients with peripheral destruction of platelets.The p-value of all the derivatives was statistically significant (level of significance less than 0.05). In patients with hypoproduction and hypersplenism,there was positive correlation between the platelet count and MPV, PDW, PCT & LCR. None of the pvalues were statistically significant. Conclusions: Platelet indices especially MPV and PDW can be used as important initial and supportive tool to differentiate between the hyperdestructive versus hypoprodution and hypersplenism cases.Platelet IndicesThrombocytopeniaPeripheral DestructionHypoproductionHypersplenismmll - Morel-lavallee LesionJournal ArticleIndiaAssociate Professor,Department of Pathology, Guru Gobind Singh Medical College& Hospital, Faridkot, PunjabAssociate Professor,Department of Pathology, Guru Gobind Singh Medical College& Hospital, Faridkot, Punjab *Corresponding AuthorProfessor & Head,Department of Pathology, Guru Gobind Singh Medical College & Hospital, Faridkot, PunjabSenior Resident,Department Preventive and Social Medicine, Guru Gobind Singh Medical College& Hospital, Faridkot, PunjabPostgraduate Resident, Department of Pathology, Guru Gobind Singh Medical College & Hospital, Faridkot, Punjab