CHACHAR, MLOKHANDE, TKUMBHAR, ACHAVAN, RSHINDE, D.2025-05-122025-05-122024-11CHACHAR M, LOKHANDE T, KUMBHAR A, CHAVAN R, SHINDE D.. OPTIMIZING DRUG DOSING IN CRITICALLY ILL PATIENTS WITH AUGMENTED RENAL CLEARANCE: A COMPREHENSIVE REVIEW AND META-ANALYSIS . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Nov; 16(11): 17-230975-14912656-0097https://imsear.searo.who.int/handle/123456789/246444Renal clearance plays a pivotal role in eliminating most administered drugs, particularly antibiotics, which is crucial for achieving therapeutic goals by maintaining plasma concentrations within the therapeutic window. Various pre-existing conditions such as renal replacement therapies, kidney or liver impairment, and enhanced excretory organ function can disrupt drug concentrations, leading to treatment failure. Augmented Renal Clearance (ARC) exacerbates this by causing rapid drug elimination, notably in critically ill patients. Consequently, careful monitoring and adjustment of drug dosages tailored to individual patient conditions and comorbidities are imperative to prevent sub-therapeutic outcomes or treatment failures. Our review highlights the necessity of dosage modifications informed by current research to optimize therapeutic outcomes in such cases. We provide a comprehensive table detailing effective antibiotics and their adjustments for ARC.Augmented renal clearanceCritically ill patientsAntibiotic dose adjustmentsTreatment failureIncreased doseeGFRCreatinine clearanceJournal ArticleIndiaDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, IndiaDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, IndiaDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, IndiaDepartment of Clinical Pharmacy, Modern College of Pharmacy, Nigdi, Pune, IndiaIntensive and Pediatric Care Clinical Pharmacist, Deenanath Mangeshkar Hospital and Research Center, Pune, India