Kamaliah, M DRoziawati, Y2009-05-272009-05-272000-09-06Kamaliah MD, Roziawati Y. Peritonitis complicating acute peritoneal dialysis in Northeast Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health. 2000 Sep; 31(3): 540-6http://imsear.searo.who.int/handle/123456789/31132The Southeast Asian Journal of Tropical Medicine and Public Health.A prospective observational study examing the incidence, predisposing factors and microbiological aspects of peritonitis complicating acute intermittent peritoneal dialysis (IPD) was performed in Hospital Universiti Sains Malaysia, a referral hospital situated in Northeast Malaysia. Over a 7- month period, a total of 126 acute IPD treatments were included involving 69 patients. The majority of patients suffered from chronic or end stage renal failure (92.7%) and nearly half (47.8%) have underlying diabetes mellitus. Peritonitis occured in 25 treatment sessions giving a frequency of 19.8% of procedures performed. The mean interval between starting dialysis and the first sign of peritonitis was 3.5 days, with 12% of peritonitis occuring before day 3 of treatment. Frequent catheter manipulation and/or leakages were identified as significant predisposing factors for peritonitis and the risk of peritonitis was increased with longer duration of IPD. Gram-negative infections were seen twice more commonly than gram-positive infections. We recommend the use of cloxacillin in combination with either an aminoglycoside or a cephalosporin as empirical antibiotic coverage until culture reports are available.engAdolescentAdultAgedAged, 80 and overDemographyFemaleGram-Negative Bacterial Infections --complicationsGram-Positive Bacterial Infections --complicationsHumansIncidenceMalaysia --epidemiologyMaleMiddle AgedPeritoneal Dialysis --adverse effectsPeritonitis --epidemiologyProspective StudiesJournal Article