Goswami, GauravUpadhyay, AmitGupta, Navratan KumarChaudhry, RajeshChawla, DeepakSreenivas, V2016-01-052016-01-052013-07Goswami Gaurav, Upadhyay Amit, Gupta Navratan Kumar, Chaudhry Rajesh, Chawla Deepak, Sreenivas V. Comparison of Analgesic Effect of Direct Breastfeeding, Oral 25% Dextrose Solution and Placebo during 1st DPT Vaccination in Healthy Term Infants: A Randomized, Placebo Controlled Trial. Indian Pediatrics. 2013 July; 50(7): 649-653.http://imsear.searo.who.int/handle/123456789/169881Objective: To compare analgesic effect of direct breast feeding, 25% dextrose solution and placebo as we give 1st intramuscular whole cell DPT injection to 6week - 3month old infants. Design: Randomized, placebo controlled trial. Setting: Immunization clinic of Department of Pediatrics, LLRM Medical College. Participants: Infants coming for their 1st DPT vaccination were randomized in to three groups of 40 each. Outcome measures: The primary outcome variable was the duration of cry after vaccination. Secondary outcome variables were Modified Facial Coding Score (MFCS) and latency of onset of cry. Results: 120 babies were equally enrolled in breast feed group, 25% dextrose fed group and distilled water fed group. Median (interquartile range) of duration of cry was significantly lower in breast fed (33.5 (17-54) seconds) and 25% dextrose fed babies (47.5 (31-67.5) seconds) as compared to babies given distilled water (80.5 (33.5-119.5) seconds) (P<0.001). MFCS at 1 min and 3 min was significantly lower in direct breast fed and dextrose fed babies. Conclusions: Direct breastfeeding and 25% dextrose act as analgesic in young infants undergoing DPT vaccination in young infants less than 3 month of age.en25% dextroseBreastfeedinguration of cryManagementDPT vaccinationPainInfantArticle