De, DipankarKaushik, AkankshaHanda, SanjeevMahajan, RahulChatterjee, DebajyotiSaikia, BimanSaikia, Uma NaharRadotra, Bishan DassMinz, Ranjana W2023-08-102023-08-102023-08De, DipankarKaushik, AkankshaHanda, SanjeevMahajan, RahulChatterjee, DebajyotiSaikia, BimanSaikia, Uma NaharRadotra, Bishan DassMinz, Ranjana W. Bullous pemphigoid in India: Review of cases registered in an autoimmune bullous disease clinic. Indian Journal of Dermatology, Venereology and Leprology. 2023 Aug; 89(4): 553-5570973-39220378-6323http://imsear.searo.who.int/handle/123456789/223158Background: Information on bullous pemphigoid in an Indian context is scarce. Aim: To report clinico-demographic profile, associated comorbidities and prescription pattern of bullous pemphigoid patients in India. Methods: This was a retrospective study, where past records of all bullous pemphigoid patients diagnosed and treated between November 2013 and October 2019 were accessed and analysed. Patients having a compatible clinical presentation with either histopathological and/or direct immunofluorescence evidence of bullous pemphigoid were included. Results: There were 96 bullous pemphigoid patients, with a male: female ratio of 1.6:1. The mean age at diagnosis was 62.5 ± 2.2 years, with mean duration of illness 27.5 ± 4.5 months before presentation. Comorbidities were present in 80 (83%) patients, with type 2 diabetes mellitus (38.5%), hypertension (36.4%) and neurological illness (16.7%) being the commonest ones. Clinically, blisters were the predominant presentation in 81 (84.4%) patients. The majority (87.5%) of patients showed a predominant eosinophilic infiltrate on histopathology. Direct immunofluorescence revealed immunoglobulin G deposits with complement C3 in 77 (80.2%) cases. The majority of patients (77.1%) were treated with oral prednisolone, either alone (11.5%) or in combination (65.6%) with other topical and systemic agents. Topical steroids were used in 29.1%, azathioprine in 28%, dapsone in 16.7% and omalizumab in 6.2% of patients. Limitations: The study is retrospective. Immunofluorescence on salt split skin, direct immunofluorescence serration pattern analysis, and immunoblotting were not performed. Hence, there is a possibility that a few included cases were suffering from other subepidermal autoimmune bullous diseases like epidermolysis bullosa acquisita or anti-p200 pemphigoid. Conclusion: Bullous pemphigoid patients in this study had a younger age of onset and showed male preponderance. Comorbidities like type 2 diabetes, hypertension and neurological disorders were freqBullous pemphigoidIndiademographyclinical featurescomorbiditiesJournal ArticleIndiaDepartments of Dermatology, Venereology and LeprologyHistopathologyImmunopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India